abstract：:One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhalation is that it aff...

journal_title：Advanced drug delivery reviews

authors： Velkov T,Abdul Rahim N,Zhou QT,Chan HK,Li J

更新日期：2015-05-01 00:00:00

abstract：:New pharmaceutical formulations must be proven as safe and effective before entering clinical trials. Also in the context of pulmonary drug delivery, preclinical models allow testing of novel antimicrobials, reducing risks and costs during their development. Such models allow reducing the complexity of the human lung,...

journal_title：Advanced drug delivery reviews

authors： Hittinger M,Juntke J,Kletting S,Schneider-Daum N,de Souza Carvalho C,Lehr CM

更新日期：2015-05-01 00:00:00

abstract：:Low back pain is generally attributed to intervertebral disc (IVD) degeneration. This is a multifactorial disease induced by genetic and environmental factors and that progresses with aging. Disc degeneration is characterized by a limited ability of IVD cells to produce functional matrix while producing abnormal amoun...

journal_title：Advanced drug delivery reviews

authors： Fontana G,See E,Pandit A

更新日期：2015-04-01 00:00:00

abstract：:Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have m...

journal_title：Advanced drug delivery reviews

authors： Lomas AJ,Ryan CN,Sorushanova A,Shologu N,Sideri AI,Tsioli V,Fthenakis GC,Tzora A,Skoufos I,Quinlan LR,O'Laighin G,Mullen AM,Kelly JL,Kearns S,Biggs M,Pandit A,Zeugolis DI

更新日期：2015-04-01 00:00:00

abstract：:The delivery of biologics is an important component in the treatment of osteoarthritis and the functional restoration of articular cartilage. Numerous factors have been implicated in the cartilage repair process, but the uncontrolled delivery of these factors may not only reduce their full reparative potential but can...

journal_title：Advanced drug delivery reviews

authors： Lam J,Lu S,Kasper FK,Mikos AG

更新日期：2015-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) remains one of the most lethal forms of cancer in the world. In this arena, utilities of microRNA (miRNA) as a sophisticated tool, in therapeutics and diagnostics, remains a prime focus among the leading researchers. It is well known that viral hepatitis, chronic alcoholism and metabolic...

journal_title：Advanced drug delivery reviews

authors： Yang N,Ekanem NR,Sakyi CA,Ray SD

更新日期：2015-01-01 00:00:00

abstract：:Angiogenesis is indispensable for solid tumor expansion, and thus it has become a major target of cancer research and anti-cancer therapies. Deciphering the arcane actions of various cell populations during tumor angiogenesis requires sophisticated research models, which could capture the dynamics and complexity of th...

journal_title：Advanced drug delivery reviews

authors： Chwalek K,Bray LJ,Werner C

更新日期：2014-12-15 00:00:00

abstract：:Despite advances in medicine and biomedical sciences, cancer still remains a major health issue. Complex interactions between tumors and their microenvironment contribute to tumor initiation and progression and also contribute to the development of drug resistant tumor cell populations. The complexity and heterogeneit...

journal_title：Advanced drug delivery reviews

authors： Sung KE,Beebe DJ

更新日期：2014-12-15 00:00:00

abstract：:Bone metastasis occurs frequently in patients with advanced breast cancer and is a major cause of morbidity and mortality in these patients. In order to advance current therapies, the mechanisms leading to the formation of bone metastases and their pathophysiology have to be better understood. Several in vitro models ...

journal_title：Advanced drug delivery reviews

authors： Taubenberger AV

更新日期：2014-12-15 00:00:00

abstract：:Despite the wide use of antibiotics, bacterial infection is still one of the leading causes of hospitalization and mortality. The clinical failure of antibiotic therapy is linked with low bioavailability, poor penetration to bacterial infection sites, and the side effects of antibiotics, as well as the antibiotic resi...

journal_title：Advanced drug delivery reviews

authors： Xiong MH,Bao Y,Yang XZ,Zhu YH,Wang J

更新日期：2014-11-30 00:00:00

abstract：:Alexander Fleming's discovery of penicillin heralded an age of antibiotic development and healthcare advances that are premised on the ability to prevent and treat bacterial infections both safely and effectively. The resultant evolution of antimicrobial resistant mechanisms and spread of bacteria bearing these geneti...

journal_title：Advanced drug delivery reviews

authors： Tang SS,Apisarnthanarak A,Hsu LY

更新日期：2014-11-30 00:00:00

abstract：:Newborn babies can require significant amounts of medication containing excipients intended to improve the drug formulation. Most medicines given to neonates have been developed for adults or older children and contain excipients thought to be safe in these age groups. Many excipients have been used widely in neonates...

journal_title：Advanced drug delivery reviews

authors： Turner MA,Duncan JC,Shah U,Metsvaht T,Varendi H,Nellis G,Lutsar I,Yakkundi S,McElnay JC,Pandya H,Mulla H,Vaconsin P,Storme T,Rieutord A,Nunn AJ

更新日期：2014-06-01 00:00:00

abstract：:Ultrasound (US) imaging is an exquisite tool for the non-invasive and real-time diagnosis of many different diseases. In this context, US contrast agents can improve lesion delineation, characterization and therapy response evaluation. US contrast agents are usually micrometer-sized gas bubbles, stabilized with soft o...

journal_title：Advanced drug delivery reviews

authors： Kiessling F,Fokong S,Bzyl J,Lederle W,Palmowski M,Lammers T

更新日期：2014-06-01 00:00:00

abstract：:The selection of drug candidates early in development has become increasingly important to minimize the use of animals and to avoid costly failures of drugs later in development. In vitro systems to predict and assess organ toxicity have so far been of limited value due to difficulties in demonstrating in vivo-relevan...

journal_title：Advanced drug delivery reviews

authors： Roth A,Singer T

更新日期：2014-04-01 00:00:00

abstract：:After 25 years of intense pre-clinical work on microencapsulated intraperitoneal islet grafts into non-immunosuppressed diabetic recipients, the application of this procedure to patients with type 1 diabetes mellitus has been a significant step forward. This result, achieved in a few centers worldwide, underlies the s...

journal_title：Advanced drug delivery reviews

authors： Calafiore R,Basta G

更新日期：2014-04-01 00:00:00

abstract：:Drug failure due to toxicity indicators remains among the primary reasons for staggering drug attrition rates during clinical studies and post-marketing surveillance. Broader validation and use of next-generation 3-D improved cell culture models are expected to improve predictive power and effectiveness of drug toxico...

journal_title：Advanced drug delivery reviews

authors： Astashkina A,Grainger DW

更新日期：2014-04-01 00:00:00

abstract：:Therapeutic cells encapsulated in immunobarrier devices have promise for treatment of a variety of human diseases without immunosuppression. The absence of sufficient oxygen supply to maintain viability and function of encapsulated tissue has been the most critical impediment to progress. Within the framework of oxyge...

journal_title：Advanced drug delivery reviews

authors： Colton CK

更新日期：2014-04-01 00:00:00

abstract：:Human genome sequencing revealed that only ~1.5% of the DNA sequence coded for proteins. More and more evidence has uncovered that a substantial part of the 98.5% so-called "junk" DNAs actually code for noncoding RNAs. Two milestones, chemical drugs and protein drugs, have already appeared in the history of drug devel...

journal_title：Advanced drug delivery reviews

authors： Shu Y,Pi F,Sharma A,Rajabi M,Haque F,Shu D,Leggas M,Evers BM,Guo P

更新日期：2014-02-01 00:00:00

abstract：:Novel materials are often commercialized without a complete assessment of the risks they pose to human health because such assessments are costly and time-consuming; additionally, sometimes the methodology needed for such an assessment does not exist. Carbon nanotubes have the potential for widespread application in e...

journal_title：Advanced drug delivery reviews

authors： Toyokuni S

更新日期：2013-12-01 00:00:00

abstract：:This article reviews the latest progresses regarding the applications of carbon nanotubes (CNTs), including single-walled carbon nanotubes (SWNTs) and multi-walled carbon nanotubes (MWNTs), as multifunctional nano-probes for biomedical imaging. Utilizing the intrinsic band-gap fluorescence of semi-conducting single-wa...

journal_title：Advanced drug delivery reviews

authors： Gong H,Peng R,Liu Z

更新日期：2013-12-01 00:00:00

abstract：:The scope of nanotechnology is gaining importance in biology and medicine. Carbon nanotubes (CNTs) have emerged as a promising tool due to their unique properties, high specific surface area, and capacity to cross biological barriers. These properties offer a variety of opportunities for applications in nanomedicine, ...

journal_title：Advanced drug delivery reviews

authors： Battigelli A,Ménard-Moyon C,Da Ros T,Prato M,Bianco A

更新日期：2013-12-01 00:00:00

abstract：:Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to be in widespread clinical use especially for management of tumors of the ovary, testes, and the head and neck. However, several dose limiting toxicities associated with platinum drug use, partial anti-tumor response in most patien...

journal_title：Advanced drug delivery reviews

authors： Oberoi HS,Nukolova NV,Kabanov AV,Bronich TK

更新日期：2013-11-01 00:00:00

abstract：:The ever increasing improvements of pharmaceutical formulations have been often obtained by means of the use of hydrogels. In particular, environmentally sensitive hydrogels have been investigated as "smart" delivery systems capable to release, at the appropriate time and site of action, entrapped drugs in response to...

journal_title：Advanced drug delivery reviews

authors： Matricardi P,Di Meo C,Coviello T,Hennink WE,Alhaique F

更新日期：2013-08-01 00:00:00

abstract：:Imaging mass spectrometry (IMS) has been a useful tool for investigating protein, peptide, drug and metabolite distributions in human and animal tissue samples for almost 15years. The major advantages of this method include a broad mass range, the ability to detect multiple analytes in a single experiment without the ...

journal_title：Advanced drug delivery reviews

authors： Weaver EM,Hummon AB

更新日期：2013-07-01 00:00:00

abstract：:Clinical pharmacogenomics, integrating genomic information with clinical practices to facilitate the prediction of drug response, has recently emerged as a vital area of public health. In clinical trials, phenotypic data on drug response are often longitudinal, with some patients dropping out early due to physiologica...

journal_title：Advanced drug delivery reviews

authors： Wang Z,Li H,Wang J,Li J,Wu R

更新日期：2013-06-30 00:00:00

abstract：:Lanthanide-doped upconverting luminescent nanoparticles (UCNPs) are promising materials for optical imaging-guided drug delivery and therapy due to their unique optical and chemical properties. UCNPs absorb low energy near-infrared (NIR) light and emit high-energy shorter wavelength photons. Their special features all...

journal_title：Advanced drug delivery reviews

authors： Shen J,Zhao L,Han G

更新日期：2013-05-01 00:00:00

abstract：:Many kinds of inorganic nanoparticles (NPs) including semiconductor, metal, metal oxide, and lanthanide-doped NPs have been developed for imaging and therapy applications. Their unique optical, magnetic, and electronic properties can be tailored by controlling the composition, size, shape, and structure. Interaction o...

journal_title：Advanced drug delivery reviews

authors： Nam J,Won N,Bang J,Jin H,Park J,Jung S,Jung S,Park Y,Kim S

更新日期：2013-05-01 00:00:00

abstract：:The role of metal ions in the body and particularly in the formation, regulation and maintenance of bone is only just starting to be unravelled. The role of some ions, such as zinc, is more clearly understood due to its central importance in proteins. However, a whole spectrum of other ions is known to affect bone for...

journal_title：Advanced drug delivery reviews

authors： Lakhkar NJ,Lee IH,Kim HW,Salih V,Wall IB,Knowles JC

更新日期：2013-04-01 00:00:00

abstract：:Using oligonucleotide-based drugs to modulate gene expression has opened a new avenue for drug discovery. In particular small interfering RNAs (siRNAs) are being rapidly recognized as promising therapeutic tools, but their poor bioavailability limits the full realization of their clinical potential. In recent years, c...

journal_title：Advanced drug delivery reviews

authors： El Andaloussi S,Lakhal S,Mäger I,Wood MJ

更新日期：2013-03-01 00:00:00

abstract：:Topical delivery to the various regions of the skin and underlying tissues, transdermal drug delivery and dermal exposure to environmental chemicals are important areas of research. Mathematical models of epidermal and dermal transport, involving penetration of a solute through various layers of the skin, metabolism i...

journal_title：Advanced drug delivery reviews

authors： Anissimov YG,Jepps OG,Dancik Y,Roberts MS

更新日期：2013-02-01 00:00:00

abstract：:We review the early developments in drug delivery from 1960 to 1990 with emphasis on the fundamental aspects of the field and how they shaped the collaboration of pharmaceutical scientists, chemists, biologists, engineers and medical scientists towards the development of advanced drug delivery systems. Emphasis is giv...

journal_title：Advanced drug delivery reviews

authors： Peppas NA

更新日期：2013-01-01 00:00:00

abstract：:Silicon is one of the most abundant chemical elements found on the Earth. Due to its unique chemical and physical properties, silicon based materials and their oxides (e.g. silica) have been used in several industries such as building and construction, electronics, food industry, consumer products and biomedical engin...

journal_title：Advanced drug delivery reviews

authors： Jaganathan H,Godin B

更新日期：2012-12-01 00:00:00

abstract：:Small interfering RNA (siRNA) that silence genes by the process of RNA interference offers a new therapeutic modality for disease treatment. Polycation-based nanoparticles termed polyplexes have been developed to maximise extracellular and intracellular siRNA delivery, a key requirement for enabling the clinical trans...

journal_title：Advanced drug delivery reviews

authors： Ballarín-González B,Howard KA

更新日期：2012-12-01 00:00:00

abstract：:Intravenous administration of low (milligram) doses of nanoparticulate materials in pigs can lead to acute cardiopulmonary, hemodynamic, hematological, biochemical and dermatological changes within minutes, mimicking the human infusion (or anaphylactoid) reactions to many state-of-the-art (nano)medicines and biologica...

journal_title：Advanced drug delivery reviews

authors： Szebeni J,Bedőcs P,Csukás D,Rosivall L,Bünger R,Urbanics R

更新日期：2012-12-01 00:00:00

abstract：:Gene delivery to bone is useful both as an experimental tool and as a potential therapeutic strategy. Among its advantages over protein delivery are the potential for directed, sustained and regulated expression of authentically processed, nascent proteins. Although no clinical trials have been initiated, there is a s...

journal_title：Advanced drug delivery reviews

authors： Evans CH

更新日期：2012-09-01 00:00:00

abstract：:Calcium phosphate cements are used as synthetic bone grafts, with several advantages, such as their osteoconductivity and injectability. Moreover, their low-temperature setting reaction and intrinsic porosity allow for the incorporation of drugs and active principles in the material. It is the aim of the present work ...

journal_title：Advanced drug delivery reviews

authors： Ginebra MP,Canal C,Espanol M,Pastorino D,Montufar EB

更新日期：2012-09-01 00:00:00

abstract：:An aging population in the developing world has led to an increase in musculoskeletal diseases such as osteoporosis and bone metastases. Left untreated many bone diseases cause debilitating pain and in the case of cancer, death. Many potential drugs are effective in treating diseases but result in side effects prevent...

journal_title：Advanced drug delivery reviews

authors： Low SA,Kopeček J

更新日期：2012-09-01 00:00:00

abstract：:Over the last three decades, a handful of photochemical mechanisms have been applied to a large number of nanoscale assemblies that encapsulate a payload to afford spatio-temporal and remote control over activity of the encapsulated payload. Many of these systems are designed with an eye towards biomedical application...

journal_title：Advanced drug delivery reviews

authors： Fomina N,Sankaranarayanan J,Almutairi A

更新日期：2012-08-01 00:00:00

abstract：:Antiepileptic drugs are commonly given orally for chronic treatment of epilepsy. The treatment of epilepsy requires administration of medications for both acute and chronic treatment using multiple types of formulations. Parenteral routes are used when the oral route is unavailable or a rapid clinical response is requ...

journal_title：Advanced drug delivery reviews

authors： Anderson GD,Saneto RP

更新日期：2012-07-01 00:00:00

abstract：:Epilepsy is the most common serious chronic neurological disorder. Current data show that one-third of patients do not respond to anti-epileptic drugs (AEDs). Most non-responsive epilepsy patients are resistant to several, often all, AEDs, even though the drugs differ from each other in pharmacokinetics, mechanisms of...

journal_title：Advanced drug delivery reviews

authors： Zhang C,Kwan P,Zuo Z,Baum L

更新日期：2012-07-01 00:00:00